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Here are some of the common symptoms of Needing a B12 Injection that you should know about and get the best care accordingly: Persistent fatigue or low energy, even after rest Weakness or lightheadedness Tingling or numbness in the hands and feet Difficulty concentrating or memory problems Mood changes, such as irritability or low mood Pale skin or a yellowish tinge Shortness of breath during simple activities Unexplained muscle weakness If these vitamin B12 deficiency symptoms sound familiar, it may be a sign that your body isn’t getting enough vitamin B12