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Without enough glutathione, mercury can damage the brain and also take the place of selenium in certain biological pathways.[ref] Related article : Mercury, detoxification, and your genes Alcohol: Acute or chronic alcohol exposure leads to a depletion of glutathione in the liver and liver damage

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However, levels of this vital antioxidant can be depleted by factors like lack of sleep, poor nutrition, and the general physical stress of early parenthood