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Finally, one of the disadvantages of these compounds, especially polyphenols and flavonoids, which also causes a limitation in their application, is that they show low bioavailability due to their poor water solubility, and for this reason, more research on how to deliver these compounds in new innovative ways, as tested using hesperetin and hesperidin nanophytosomes, is of utmost importance

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The conversion of PR-Ub and ADPR-Ub into native ubiquitin suggests that the accumulation of these ubiquitin derivatives interferes with the intracellular replication of L

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