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ROS can cause DNA, protein and membrane damage thus a decreased expression of GSH has been linked to atherosclerosis, HIV, certain cancers and rheumatoid arthritis [45]

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The mechanism of actions in medical plants is broad, including regulating intestinal microbiota and permeability, upregulating both mRNA and protein expressions of claudin-1, lowering extracellular signal-regulated kinase activation in hepatocytes, suppressing MLCK-MLC phosphorylation signaling pathway, and protecting on IECs against LPS-insult [198]