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Enebo and colleagues (Lancet, 2021) characterised the pharmacokinetic and pharmacodynamic profile of co-administered cagrilintide and semaglutide, and subsequent work by Lau and colleagues (Lancet, 2021) and Frias and colleagues (Lancet, 2023) has documented additive effects on body weight and metabolic markers in clinical research populations

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For the six favorable votes, if the agency agrees, it must open formal notice-and-comment rulemaking to amend the 503A list