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When phenol and hydroquinone are administered together, they reproduce benzene's myelotoxic effects.2425 Phenol and phenol-derived metabolites (eg 4,4′-diphenoquinone) inhibit topoisomerase II and enhance the genotoxic effects of hydroquinone.26 Many chemotherapeutic drugs that inhibit topoisomerase II also induce leukemias.27 The co-administration of phenol and hydroquinone to mice induces micronuclei and oxidative DNA damage in the bone marrow in a manner similar to benzene.262829 Further, combinations of the phenolic metabolites of benzene enhance DNA adduct formation.3031 It has therefore been suggested that all the phenolic metabolites of benzene play a role in benzene-induced toxicity, and that it is the combination that is most toxic.2432 Phenol and hydroquinone produce genetic damage of the type found in leukemia Quinones derived from phenol, catechol, hydroquinone and 1,2,4-benzenetriol cause various forms of genetic damage including chromosome breakage and aneuploidy.2633 Aneuploidy is the loss or gain of whole chromosomes and is a frequent clonal aberration in leukemia
