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11 , 16 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 49 , 56 , 60 The mechanisms of action of adaptogens are mainly associated with metabolic regulation via extracellular communication of hypothalamic–pituitary–adrenal (HPA)‐axis hormones and activation of intracellular adaptive stress response signaling pathways