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Activated T cells require increased metabolism of glucose and glutamine for proliferation, and deprivation or inhibition of synthesis of these molecules reduces T cell proliferation (3, 4)

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Owing to ROS in cells, mainly coming from the electron leakage and damaging the mitochondrial respiratory chain, the effect of HIF-1 on ROS is often regarded as acting on the respiratory chain, which mainly affected ROS production by directly targeting the mitochondrial respiratory chain complex

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