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Patients with AKI are clinically characterized by impaired renal tubular function, acute renal failure, a reduction in whole blood cells, anemia, physical tremors, weight loss, gastrointestinal dysfunction, lethargy, and orbital tightening, which limit the antitumor use of cisplatin [5]

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If you're applying GHK-Cu at the same time as AHAs, BHAs, or high-concentration retinoids, you're asking for irritation