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The alternative hapten model states that the presentation of NAPQI-protein adduct peptides by the human leukocyte antigen (HLA) on antigen presenting cells (APCs), leads to the activation of helper T (Th) cells and ultimately cytotoxic T (Tc) cells

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Results: We identified a total of 237,905 patients with primary diagnosis of Hepatocellular carcinoma in 2016 to 2020, Of whom 23.3% (55,514) had hyponatremia on presentation