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Recent findings in the fly and mouse models of FRDA actually support a mechanism that is independent of ROS that links neurodegeneration and iron accumulation via the sphingolipid pathway (Chen et al., 2016a,b)

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One investigation indicated that estrogen enhances C3 secretion in rat uterine epithelium, a phenomenon not replicated in the liver (82), suggesting that the effects of estrogen may be tissue-specific and cannot be generalized as universally activating the complement system