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The PIAS2 signaling pathway in PD involves multiple type I interferons (IFNs), their receptors, and downstream molecules, including dysregulation of the IFNG , IFNGR1 , and STAT4 genes, as well as up-regulation of negative regulators such as PIAS2 , suggesting a blockade of the IFNβ-IFNAR signaling pathway

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The visualization of all simulation results was conducted using the open-source software PyMOL 2.04