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Only GlyNAC supplementation in OA resulted in significantly improved (a) GSH concentrations by 121% after 2-weeks, and by 164% after 16-weeks to levels not different from YA-0w (Supplementary Figure S1), and (b) muscle GCLC and GSS expression (with a trend toward improvement for GCLM

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GLP-1 medications like semaglutide and tirzepatide act faster and stronger, with large trials showing 10% to 15%-plus body-weight reductions