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For example, in mature plant cells, the vacuole typically occupies nearly 90% of the cell volume 54 , leaving limited space for other organelles to move freely and transport rapidly, particularly for large or tubular organelles

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Importantly, MGF promotes proliferation without premature differentiation, expanding the progenitor cell pool before differentiation signals (from later IGF-1Ea expression) drive myoblast fusion into mature myofibers