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Overall, BCAA metabolism exemplifies a competitive and context-dependent metabolic axis within the TME, where tumor and immune cells vie for the same essential resources to sustain divergent functional programs

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Indeed, H 3 receptors are found to be upregulated in Hdc KO mice, and chemogenetic activation of these receptors in the dorsal striatum can precipitate stereotypies (Rapanelli et al., 2017) suggesting that histamine, and specifically the H 3 receptor in the dorsal striatum, are contributing to the repetitive movements that are a prominent feature of TS