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A 2025 review by Mortazavi and Mohammadi Vadoud in BioImpacts flagged skin permeability as the main barrier to translating topical GHK-Cu data into clinical outcomes — the compound does not reliably penetrate intact skin at concentrations used in topical products

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A better method is to use retinoids at night and exfoliate 1-2 times per week, but never on the same day as retinoids