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The production and accumulation of amyloid β peptide (Aβ) in the brain plays important roles in the initiation and development of Alzheimer’s disease (AD) ( 25-35 ) in mouse cortical neurons while elevate intracellular GSH, attenuating the cytotoxicity of Aβ 25-35 to neurons ( cornu ammonis regions of mouse hippocampus (which is critical in memory and cognition) and alleviate the cognitive impairment, as revealed by Y-maze, passive avoidance and water maze tests

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Cytotoxic Effect of Brain Macrophages on Developing Neurons