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50 & Target [2] In Vitro Isotretinoin (13-cis-Retinoic acid) may act as a pro-drug that is converted intracellularly to metabolites that are agonists for RAR and RXR nuclear receptors [1]

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10.1158/0008-5472.CAN-12-3831 [DOI] [PubMed] [Google Scholar] 187.Wu K, Cheng H, Chang T