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In rare monogenic disorders such as HD, evidence from patients with HD and rodent models suggests that dysfunctional BDNF-TrkB signalling is involved in the disorder development 10

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Amino acids can be classified as either essential (His, Iso, Leu, Lys, Met, Phe, Thr, Trp, and Val), meaning they must be acquired from food, or nonessential, encompassing amino acids that can be enzymatically synthesized by cells from other biomolecules, such as glucose and essential amino acids