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These medications bind to the same receptors as natural incretins but last for hours or days instead of minutes

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Damage to the BBB typically occurs within minutes to hours following the injury and involves generation of reactive oxygen species and the activation of matrix metalloproteases (MMPs), such as MMP-2, MMP-3 and MMP-9 and MMP-12 that degrade the basement membrane, tight junction proteins and damage cellular components of the neurovascular unit, such as pericytes