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Cell-meditated immunity involves protein antigens that are first degraded in the endocytic vesicles of macrophages and dendritic cells, so that the smaller peptides are presented on the cell surface to activate proliferation of antigen-specific T cells

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VEGF-C signaling through VEGFR-3 involves the activation of Cdc-related kinase (CRK) I/II and C-Jun N-terminal kinase (JNK) 1/2 [7,8,34]