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doi: 10.3168/jds.S0022-0302(95)76730-3

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Briefly, after entering the mitochondria via a carrier for basic amino acids (SLC25A29), 2-aminoadipic acid semialdehyde (AASA) synthase, a bifunctional enzyme with domains for lysine–ketoglutarate reductase and saccharopine dehydrogenase, catalyzes the gradual conversion of lysine to saccharopine and AASA (allysine)

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