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In chemotherapy-sensitive patients, Keap1 (Kelch-like ECH-associated protein 1) binds to NRF2 and mediates NRF2 ubiquitination via the Cul3-E3 ligase complex, promoting its degradation and maintaining NRF2 at low levels [32]

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Originally developed as a synthetic version of thymosin beta-4 , TB‑500 is now being explored by athletes, biohackers, and clinicians for its regenerative potential — particularly in tendons, ligaments, and muscle tissue