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C-terminal fragment → lipolytic domain isolated from the parent hormone Beta-3 adrenergic signaling → elevated adipocyte cyclic AMP Hormone-sensitive lipase activation → triglyceride hydrolysis Absent somatogenic domain → no IGF-1 elevation in published models N-terminal tyrosine → stability modification over the unmodified fragment Core Areas of Scientific Investigation Structure-Function Mapping: AOD-9604 helps localise the lipolytic domain of growth hormone within its 191-residue sequence

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