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Mitochondrial fusion and fission in cells play an important role in cell proliferation and differentiation through the elimination of damaged mitochondria and the introduction of maximized ATP production [58,60]

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NGRA uses information from NAMs and conservative decision-making to protect human health, aligning with the way regulatory decision-making has been conducted using traditional approaches ( Inspired by the NGRA concepts applied to other safety areas, such as systemic toxicity (Figure 1)