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A recent study using single molecule imaging confirmed that all apoE isoforms associate with Aβ to form fibrils and that the presence of non-lipidated apoE slowed the aggregation process and formed large early-stage Aβ co-aggregates, supporting a role of non-lipidated apoE in stabilizing intermediate complexes with Aβ [50]

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For references and more information, see the section on cardiovascular disease in the Phytosterols article