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Chronic exposure to these drugs depletes presynaptic monoamine stores, impairs long-term neuronal signaling, and induces neurodegeneration ( 4.2 Oxidative stress and mitochondrial dysfunction The excessive release of monoamines promotes ROS formation through the auto-oxidation of dopamine and norepinephrine

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Serum B12 between 145 and 220 pmol/L (insufficiency range): Usually no delay, but I start vitamin B12 supplementation at the follow-up consultation and may recheck at 4 to 6 weeks, depending on when surgery is scheduled