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Catalase, a tetrameric ferriheme oxidoreductase, facilitates the breakdown of hydrogen peroxide into water and oxygen (259) Glutathione peroxidase, a selenium-dependent oxidoreductase, utilises hydrogen peroxide or organic hydroperoxides as substrates, with reduced glutathione (GSH) acting as the electron donor (260) The reactions include: H 2 O 2 + 2GSH → 2H 2 O + GS–SG and ROOH + 2GSH → ROH + H 2 O + GS–SG (261, 262)