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The two models were employed to address the limitations of the Fine-Gray model, which does not adequately incorporate the TDC, and the Cox model, which does not account for competing risks

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Only after these boundary conditions have been defined can the mechanistic links discussed in the present review, including mitochondrial regulation, neuroinflammation, autophagy, HPA axis regulation and synaptic plasticity, be tested as clinically meaningful targets rather than only as preclinical pathway-level observations (21,270,272,275)