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Notably, B cells have been shown to also harbor dual roles: chemotherapy-induced ICOSL + B cells enhance T-cell–mediated antitumor immunity (157), while pathological antibodies activate NF-κB–HIF1α–COX2 signaling in tumor cells to form pro-metastatic lymph node niches (158)

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Contains reduced form of glutathione (GSH), a form that can readily neutralize free radicals by donating electrons