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For instance, peptides such as apelin, apelin-13, formononetin, ANP, mangiferin, and pHBSP have shown significant protective effects by modulating oxidative stress, reducing inflammatory responses, and inhibiting apoptotic pathways

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Reported phase 1b and phase 2 data describe dose-ranging pharmacokinetic and pharmacodynamic profiles, while structural biology studies have begun to map its binding mode across the three class B GPCRs