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Potential implications of the new pharmacotherapies on obesity management The mean WL in clinical trials with the most efficacious new obesity pharmacotherapies ranges between 15% and 25% at 1 year (and it may be even higher for some agents that have not reached weight plateau at study completion)

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is supported by NIH grants P30CA014051, R01CA211184, R01CA245314, R01CA034992, R01DK126545, R01CA257523, and U54CA224068