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Furthermore, SLC7A11 -deficient mice develop normally and are healthy [79] suggesting that compounds targeting system x c − with high specificity may likely have minimal side effects under pre-clinical and clinical settings

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Multiple studies 10-13 have found signs of inflammation in LC and CFS patients, including higher serum cytokine levels 10-12 that are associated with patient-reported fatigue severity 10 and changes in both lymphocyte and monocyte cell populations 12 among LC donors