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3 Targeting gut microbiota for NAFLD NAFLD is a major cause of chronic liver disease worldwide and is prone to developing into liver fibrosis, cirrhosis and even HCC ( The exploration of enterohepatic circulation has confirmed that gut microbiota dysbiosis is closely related to the progression of NAFLD, which not only manifested in the great changes in the gut microbiota diversity and abundance in NAFLD patients compared with healthy subjects but also reflected that gut microbiota disrupted the inflammatory balance and glucose and lipid metabolism through intestinal metabolites ( Figure 2

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