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They share similarities in terms of signaling pathways, but the fundamental difference between the two lies in the fact that CARs possess an engineered scFv domain able to recognize tumor antigens not bound by MHC molecules and, instead, expressed directly on the membrane

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Given the presence of various negative feedback or loop regulatory mechanisms in biological cells that determine the homeostatic levels of key cellular factors, including iron and NAD + , it is an interesting topic to clarify how iron overload affects intracellular NAD +

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