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revealed that the B-repeat segment of a cell surface protein of Staphylococcus aureus SdrD is capable of binding of 14 Ca 2+ ions, and that, based on the circular dichroism and Trp fluorescence analysis, concluded that although the metal-free form is strongly disorganized, the Ca 2+ -bound form is well folded (Josefsson et al., 1998)

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Therefore, regulating iron metabolism is one of the key strategies to target ferroptosis in the treatment of human diseases