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Mitochondria are the main site of ROS production, of which more than 90% are produced by mitochondria in the normal metabolism and energy supply of the electron transport chain ( Non-enzymatic antioxidants scavenge free radicals by interacting directly with them

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Similarly, cyclic hydrostatic pressure enhances the chondrogenic differentiation of BMSCs (Miyanishi et al., 2006) and AD-MSCs (Ogawa et al., 2009) in a dose- and time-dependent manner, and shows synergistic effects when co-cultured with nucleus pulposus cells (Li Z