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A Nature Scientific Reports 2016 study showed GHK-Cu had no cytotoxicity to human keratinocytes at concentrations up to 5,800 μM over 72 hours and did NOT induce inflammatory biomarkers (IL-1α, IL-8, HSPA1A, FOSL1) unlike other copper compounds, concluding GHK-Cu has a low potential of inducing skin irritation

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