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patients undergoing alternative cancer treatment because of a contraindication to fluoropyrimidines Comparator Included: wild-type patients or DPYD carriers with no fluoropyrimidine dose adjustment before the start of treatment Excluded: patients who had a fluoropyrimidine dose adjustment before the start of treatment OUTCOME MEASURES Clinical Validity Severe fluoropyrimidine-related toxicity, overall and by type (hematological, gastrointestinal, dermatological) Clinical sensitivity, specificity, and positive and negative predictive value of DPYD genotyping (three to four variants) for the prediction of fluoropyrimidine-associated toxicity Toxicity-related changes to fluoropyrimidine-based treatment (i.e., dose reduction or increase, treatment delay and discontinuation) Toxicity-related hospitalization Toxicity-related mortality Clinical Utility Fluoropyrimidine dose reduction, increase, discontinuation
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Select Pack Size:30 Strips (Most Popular)
And you should always verify your numbers independently
