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The Scientist - The incidence of Lyme disease has risen steadily in recent years in the US and Canada, driven by climate change and a host of other interconnected factors. Lyme disease

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The principal responses to histamine binding to the H 2 R are stimulation of gastric acid secretion, increased sinus rhythm (cardiac rhythm initiated via depolarization from the sinus node), smooth muscle relaxation, inhibition of antibody synthesis, inhibition of T-cell proliferation and inhibition of cytokine production