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The transcription factor NRF2 (also known as NFE2L2) is activated by oxidative stress and is a master regulator of the enzymes required for glutathione synthesis, as well as SLC7A11 to increase cystine uptake (Habib et al., 2015

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23 In this case, the patient was instructed to discontinue DIM and reported that visual improvement began two weeks after, with resolution to baseline after eight weeks