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For patients with hepatic impairment or reduced renal function, a reduction in the induction dose to 30 mg and the maintenance dose to 15 mg is recommended [92]

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A promising approach in estrogen therapy is the development of brain-targeted estrogen treatments, including prodrugs such as 10β,17β-dihydroxyestra-1,4-dien-3-one (DHED), which is administered systemically but converted to 17β-estradiol in the brain

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