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Although the response of APL cells to As 2 O 3 has been linked to degradation of the PML/RAR α fusion oncoprotein, there is evidence that PML/RAR α expression is not the only mediator of arsenic sensitivity

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All known mitochondrial zinc-dependent metalloproteins are synthesized in the cytoplasm and imported into the organelle as unfolded polypeptides, requiring matrix-localized folding and metallation machinery for activation