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Symptoms of B12 Deficiency Vitamin B12 deficiency can, have a number of symptoms: Numbness or tingling in hands and feet Weak muscles Trouble walking Nausea Decreased appetite and weight loss Fatigue Irritability Diarrhea Fast heart rate A smooth and tender tongue Brain fog and cognitive issues

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by mutations in the AGAT or GAMT genes – SAM cannot be utilised and circulates at elevated levels