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Locally acting autocrine/paracrine molecules in the growth plate include Indian hedgehog (Ihh), parathyroid hormone-related protein (PTHrP), fibroblast growth factors (FGFs) (including FGF1, −2, −9 and −18), bone morphogenic proteins (BMPs) (including BMP2–7), vascular endothelial growth factor (VEGF), IGF-1, and Wnt [2,11,81,85,86,89,90]