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Symptoms of B12 Deficiency If left untreated, a B12 deficiency can lead to several serious symptoms , including: Fatigue and weakness Pale or jaundiced skin Numbness or tingling in hands and feet (due to nerve damage) Difficulty walking , balance problems Memory problems , difficulty concentrating (brain fog) Mood changes , such as depression or irritability Glossitis (inflammation of the tongue) and mouth sores Shortness of breath and dizziness (due to anemia) Heart palpitations B12 injections are the fastest and most effective way to treat a Vitamin B12 deficiency because they deliver the vitamin directly into the bloodstream, bypassing the digestive system