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periportal hepatocytes may contain nearly twice the centrilobular concentration, enterocytes at the villus tip have a higher content than the crypts, and renal proximal tubular cells have more GSH than other parts of the nephron (56)

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Ablation of the NLRP3 inflammasome or treatment with the antioxidant N-acetylcysteine (NAC) markedly attenuated these effects [218]