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⁷ Receptor architecture — Willard measures tirzepatide as GIPR-forward and GLP-1R-biased: full cAMP signaling with reduced GLP-1R beta-arrestin recruitment, not simply “two full native hormones in one molecule.” The occupancy chart combines those functional-potency values with free exposure using albumin Kd 1.86 μM and free fraction 0.29%

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doi: 10.1186/1471-2172-13-71 [DOI] [PMC free article] [PubMed] [Google Scholar] 171