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Activated NLRP3 inflammasomes directly activate caspase-1, which cleaves GSDMD and generates mature IL-1β and IL-18, thereby executing the canonical pyroptotic program

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Analyzing the distribution of the thiol compounds across the CNS indicated that, in astrocytes, the unique combination of GSH and CSH levels renders these cells a potential hot spot of ROS formation, from which, under certain pathophysiologic circumstances, neuronal damage may arise