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In conclusion, the antipyretic effect of CX is related to the inhibition of the expression of COX-2, PGE2, the reduction of cAMP in the hypothalamus, the regulation of the neurotransmitter, and suppressive effects on TNF-α-mediated NF-κB activation

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Severe hypoglycemia leading to hypoglycemic seizures has been observed with INCRELEX treatment [see Adverse Reactions (6.1)]